intra- and inter-individual variability of nifedipine pa pharmacokinetics
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intra- and inter-individual variability of nifedipine pa pharmacokinetics by Burton Chan

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Published .
Written in English


Book details:

Edition Notes

Industrial Pharmacy Residency Report: Apotex, Inc.

The Physical Object
Pagination74 leaves
Number of Pages74
ID Numbers
Open LibraryOL19066412M

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  After nifedipine PA there was also a rapid rise in plasma concentration of drug achieving a Cmax of (36) ng/mL with a tmax of (58) . When nifedipine was administered intravenously the mean t1/2 beta was +/- h, the mean CL was + l/, and the mean V1 . Relationship between pharmacokinetics and pharmacodynamics. Kleinbloesem CH, van Brummelen P, Breimer DD. The availability of specific chemical assays and the development of appropriate biological models have made it feasible to study the relationship between the pharmacokinetics and the pharmacodynamics of nifedipine, a relationship that is Cited by: Definitions In pharmacology. In pharmacology, bioavailability is a measurement of the rate and extent to which a drug reaches at the site of action. It is denoted by the letter f (or, if expressed in percent, by F).. In nutritional sciences. In nutritional sciences, which covers the intake of nutrients and non-drug dietary ingredients, the concept of bioavailability lacks the well-defined.

  It has been comprehensively described that extensive variability of anti-hypertensive drugs plasma concentrations in patients, due to the Pmediated drugs metabolism, has a great impact and influence on the clinical outcome as well as on the drugs' response [].Among the antihypertensive drugs, the ACE inhibitor captopril, the beta blockers Cited by: Methods. The effect of nifedipine on P-glycoprotein (P-gp) and cytochrome P (CYP) 3A4 activity was evaluated. The pharmacokinetic parameters of repaglinide and blood glucose concentrations were also determined in rats after oral ( mg/kg) and intravenous ( mg/kg) administration of repaglinide to rats in the presence and absence of nifedipine (1 and 3 mg/kg).Cited by: A prerequisite for oral administration is dissolution of the drug in water to allow absorption in the GI tract; however, approximately 40% of NCEs including anticancer drugs are insoluble in water which leads to poor absorption, poor BA, and high intra- and inter-individual Cited by: Telmisartan is a benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in .

Fish oil can be obtained from eating fish or by taking that are especially rich in the beneficial oils known as omega-3 fatty acids include mackerel, herring, tuna, salmon, cod liver, whale blubber, and seal of the most important omega-3 fatty acids contained in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Each of these factors may vary from patient to patient (inter-individual variation), and indeed in the same patient over time (intra-individual variation). In clinical trials, inter-individual variation is a critical measurement used to assess the bioavailability differences from patient to patient in order to ensure predictable dosing. Inter-individual variability in plasma drug concentrations from the same dose is large (e.g. phenytoin). 4. There is a low therapeutic index (e.g. if the ratio of toxic concentration/effective. The zero order absorption phases lasted for 31 and 52 minutes respectively, the second phase starting at the end of the first phase, though the duration of the phases varied considerably between individuals. Inter-individual variability was estimated for CL/F, LAG1, D1, Ka2 and D2. Parameters were estimated with good precision.